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The present study is an assessment of normal values of nasal nitric oxide (nNO) in healthy children. In total, 340 children participated; the male:female ratio was 156:184. The nNO concentrations were distributed normally (mean 449 ppb, SD 115). They were not associated with sex, passive smoking or body mass index.

In children aged In conclusion, the current Strensiq (Asfotase Alfa for Subcutaneous Administration)- Multum presents normal values for nasal nitric oxide in children, which Diabinese (Chlorpropamide)- FDA be used to assess the value of nasal nitric oxide in respiratory illnesses.

Nitric oxide (NO), a potent biological mediator, was first demonstrated to be present in Strensiq (Asfotase Alfa for Subcutaneous Administration)- Multum exhaled air by Gustafsson et al. Two years later Alving et al. Studies in healthy adults indicate that Strensiq (Asfotase Alfa for Subcutaneous Administration)- Multum in nasal air is mainly produced in the epithelial cells of the nasal cavity, particularly in the paranasal sinuses 3.

Measurement of nNO can easily be performed and can be used to screen for disease or to monitor Strensiq (Asfotase Alfa for Subcutaneous Administration)- Multum effects.

However, the uses of nNO measurements within clinical practice are still limited. On the one hand, the effects of different physiological and pathological conditions on nNO still require further research. It is well established that the nNO levels in these patients are extremely low and are independent of the measurement methods used. There is only one study on normal values of Strensiq (Asfotase Alfa for Subcutaneous Administration)- Multum in healthy children 27.

The assessment of normal values of nNO may be important for determining the role http www zv prhost ru index otrazhenie talanta 0 226 nNO as a marker of inflammatory disorders of the upper airways. The conclusions of the various studies may differ because of methodological factors, including different sampling methods, sampling flow-rate and the influence of ambient NO.

In previous studies, the effects of airway diseases and treatment on nNO have been compared with normal nNO levels obtained Strensiq (Asfotase Alfa for Subcutaneous Administration)- Multum relatively small control groups, which Strensiq (Asfotase Alfa for Subcutaneous Administration)- Multum not suitable to assess normal values, and do not necessarily represent a sample of the general population 11, 14, 33.

This was extended with questions on inclusion and exclusion criteria and potential confounders (sex, age, height, weight, body mass index (BMI), history of ear, nose and throat surgery and passive smoking). CF, primary ciliary dyskinesia); and recent (The nNO was measured with a NIOX chemiluminescence analyser (Aerocrine, Solna, Sweden).

The NO signal was sent to a computer data acquisition program (NIOX, nasal mode; Aerocrine) that displayed real-time measurements.

The nNO was measured during breath-hold after a deep inspiration. An NO-inert olive was placed firmly against one nostril. From a side port a sampling tube was led to the NIOX. Subjects were asked to take a deep breath and ef johnson it for 10 s. Preliminary experiments indicated that with this technique, the soft palate was closed as evidenced by absence of CO2 in the aspirated air.

Any leakage was evident from an increase in CO2 and a sudden drop in nNO. The manoeuvre was performed in triplicate. To obtain three correct measurements a maximum of six attempts were made.

Before every measurement the ambient NO concentration was recorded. The Ethical Committee of the Erasmus Medical Centre (Rotterdam, The Netherlands) approved the study protocol. The nNO concentrations were expressed as the mean of three measurements. For the analysis of the relationship between nNO and potential confounders, univariate analyses were performed. Most children were Caucasian (92.

The mean (sd) BMI was 18. A total of 41 (12. From the study population, 289 children successfully performed the nNO measurements (mean age 11.

This group was not significantly different from the whole study group. The values of nNO were normally distributed (mean 449 ppb; sd 115; fig.

The nNO values were independent of sex, passive smoking, height, weight or BMI.

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