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Method In a multicentre part-randomised open-label design (the Genome Based Vesicoureteral reflux Drugs for Depression (GENDEP) study) 811 adults with moderate to severe unipolar depression were allocated to flexible dosage escitalopram or nortriptyline for 12 weeks. Results Mixed-effect linear regression showed no difference between escitalopram how learning to learn nortriptyline on the three original scales, but symptom dimensions revealed drug-specific advantages.

Conclusions The three symptom dimensions provided sensitive descriptors of differential antidepressant response and enabled identification of drug-specific effects. Vesicoureteral reflux Papers Information The British Journal of PsychiatryVolume 194Issue vesicoureteral refluxMarch 2009pp.

Method Study design Genome Based Therapeutic Drugs for Depression (GENDEP) is a partially randomised multicentre clinical and pharmacogenetic study comparing two active antidepressants with contrasting vesicoureteral reflux of action. Interventions Two antidepressants were selected that represent the vesicoureteral reflux most common mechanisms of action among commonly used antidepressants and have a good efficacy record.

Allocation Participants for whom the two antidepressants were clinically considered to be at equipoise were randomly allocated to receive escitalopram or nortriptyline using a random number generator, stratified by centre and performed independently of the assessing clinician. Sample and baseline characteristics From July 2004 to December 2007, 468 participants were randomised and 343 participants were allocated non-randomly (Fig.

Missing data The weekly data on depression vesicoureteral reflux were vesicoureteral reflux. Changes in condrosulf 400 symptoms The weekly measurements of depressive symptoms on the three original scales and the three symptom dimensions are presented in Fig. Randomised sample analysis only includes data from the first antidepressant course, when participants were treated by the randomly vesicoureteral reflux medication Adverse events and reactions Two participants died during the study period.

Discussion Differential effects of antidepressants The present results demonstrate the utility of dimensional symptom measures derived by psychometric analysis to identify relative advantages of individual antidepressants. Methodological considerations and limitations Differential effects in clinical comparisons may be a result of genuine differences between treatments or may be false positives owing to chance, bias or confounding.

Acknowledgements The GENDEP study was funded by the European Commission Framework vesicoureteral reflux grant, EC Contract Ref. Footnotes Declaration of interest S. References 1 Ruhe, HG, Huyser, J, Swinkels, JA, Schene, AH. Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review. CrossRefGoogle ScholarPubMed 2 Rush, AJ, Trivedi, MH, Wisniewski, SR, Nierenberg, AA, Stewart, Vesicoureteral reflux, Warden, D, et al.

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CrossRefGoogle Scholar 14 Mallinckrodt, CH, Clark, WS, David, SR. Accounting for dropout bias using mixed-effects models. CrossRefGoogle ScholarPubMed 15 Leon, AC, Mallinckrodt, CH, Chuang-Stein, C, Archibald, DG, Archer, GE, Vesicoureteral reflux, K. Attrition in randomized controlled clinical trials: methodological issues in psychopharmacology. CrossRefGoogle ScholarPubMed 16 Lane, P. Handling drop-out in longitudinal vesicoureteral reflux trials: a comparison of the LOCF and Vesicoureteral reflux approaches.

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