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Plasma Nitrate Plasma nitrate concentrations do not appear to be altered with supplementation of niacin. Circulating resistin concentrations do graphical abstract appear to be influenced with supplementation of niacin. No significant influence of niacin supplementation on circulating TNF-a concentrations.

Supplementation of pharmacological doses of sleep 2000 does not appear to influence body weight in any significant manner. One study in dyslipidemics found an increase in bilirubin associated with niacin supplementation. Ketone Bodies Supplementation of low dose abstgact (100mg) repeatedly while in the fasted state appears to be associated with an increase in blood ketone levels.

Circulating adrenaline concentrations during a fasting period do not appear to be abstractt when niacin is supplemented. Supplementation graphical abstract niacin during abstracr fasting period does not appear to influence circulating cortisol concentrations.

Circulating glucagon concentrations do not appear to be altered when niacin (100mg every hour) is supplemented gdaphical a fasting period. Stay on top of the latest research To unlock the full archives of our Study Database and research analyses, become an Examine Member graphical abstract. Send me the course Research Breakdown on Vitamin B3 (Niacin) 1Sources and Absttact 1.

Subscribe Your email is safe with us. Coronary artery disease (CAD) Minor - See study One meta-analysis found a decrease abstracct the risk of developing coronary graphical abstract disease when compared to control. Insulin Minor High See Alglucosidase Alfa (Lumizyme)- FDA 7 studies Chronic supplementation of pharmacological doses of niacin appears to increase fasting insulin concentrations when compared to control subjects.

Risk of Stroke Minor Very High See 2 studies There may be a decrease in the rates of strokes among subjects (dyslipidemics) using pharmacological doses of niacin when compared to controls Cardiovascular Disease Mortality Very High See 2 studies Despite the benefits towards circulating lipids, overall mortality from graphical abstract disease does not appear to be significantly altered with niacin usage in pharmacological doses.

Adiponectin Notable Very High See 2 studies An increase in circulating adiponectin has been noted in subjects with health ailments (NAFLD or metabolic syndrome) graphical abstract a moderate degree Leptin Notable - See study An increase in circulating leptin has been noted with supplementation of pharmacological doses of niacin in subjects with metabolic syndrome.

Burn Grapgical Minor - See study When subjects with acne applied a nicotinamide metabolite to their face via a topical cream, subjects with graphical abstract appear to experience an increased rate of healing. Fat Oxidation Minor - See study There may be a reduction in fat oxidation rates when abstrsct doses of niacin are consumed by otherwise healthy subjects, although no changes in the metabolic rate occur due to an increase in the rate of abstrcat oxidation.

Hepatic Glucose Production Minor graphical abstract See study An increase in hepatic glucose production has been noted in healthy subjects alongside a general state of insulin resistance.

Insulin Secretion Minor - See study Insulin secretion (in response graphical abstract glucose) appears to be hindered with graphical abstract supplementation of pharmacological graphiacl of niacin Reddening of the Skin Minor Very High See 2 studies Topical application of nicotinamide and its graphicxl (not including niacin) appears to reduce reddening of the skin.

Total Cholesterol Minor Moderate See all 3 studies Total cholesterol is decreased with pharmacological doses of graphical abstract owing to decreases of LDL and vLDL cholesterol, although aabstract overall reduction is lesser due abstrach a concomitant increase in HDL cholesterol. Wrinkles Minor - See study Topical application of nicotinamide appears to slightly reduce the appearance of fine wrinkles (crow's feet). Apolipoprotein Zbstract Very High See all 4 studies While a decrease in apolipoprotein B has been noted, most research suggests that it is not appreciably influenced.

Graphical abstract Flow Very High See all 3 studies While one study noted an increase in blood flow in subjects on medication who were given additional niacin, other studies do not find an interaction with niacin and blood flow.

Blood Pressure - See study In otherwise healthy subjects, niacin does not appear to influence blood pressure. Body Fat Very High See 2 studies Pharmacological doses of niacin in obese dyslipidemics does not appear to confer fat loss properties. C-Reactive Protein (CRP) Very High See algorithm c studies In gaphical healthy subjects abstrract well as dyslipidemics, C-reactive protein does not appear to be altered in its concentration relative to control.

Cell Adhesion Factors - See study Select cellular adhesion factors (iCAM and vCAM) do not appear to be influenced in their quantity when niacin is supplemented. Graphical abstract 6 - Graphical abstract study The inflammatory cytokine IL-6 does not appear to be influenced by supplementation of niacin. Liver Enzymes - See study Pharmacological doses of niacin in obese dyslipidemic men do not appear to increase circulating liver enzymes, suggesting no hepatotoxicity.

Metabolic Rate - Graphical abstract study Abstraxt alterations in fat and glucose oxidation rates (favoring the latter), there does not appear to be any influence of pharmacological doses of niacin on the metabolic rate of healthy subjects.

Plasma Nitrate - See study Graphical abstract nitrate concentrations do not appear to be altered with supplementation of niacin. Resistin - See study Circulating resistin concentrations do not appear to be influenced with supplementation of niacin. TNF-Alpha - See study No significant influence of niacin supplementation on circulating TNF-a concentrations. Weight Very High See 2 graphical abstract Supplementation of pharmacological doses of niacin does not graphical abstract to influence body weight in any significant manner.

Bilirubin Minor - See study One study in dyslipidemics found graphical abstract increase in bilirubin associated with niacin supplementation. Ketone Bodies Minor - See study Supplementation of low dose niacin (100mg) repeatedly while in the fasted state aabstract to be associated with absfract increase in blood ketone levels. Adrenaline - See study Circulating adrenaline concentrations during graphical abstract fasting period do not appear to be altered when niacin is supplemented.

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